Dr.
Anil Bhatt
Ultraflux Dialysis: Revolutionising Kidney Care with Advanced Technology
A Patient’s Guide by
Dr. Anil Prasad Bhatt, MD, DM (Nephrology, AIIMS)
Director – Nephrology and Kidney Transplant
Max Super Speciality Hospital, Noida; Holy Family Hospital, New Delhi; and Renacare Centre
for Kidney Disease and Research
For millions worldwide facing kidney failure, dialysis is a lifeline. Ultraflux dialysis, an
innovative hemodialysis method, delivers enhanced efficiency and health benefits, marking a
significant leap in kidney care. Renacare Dialysis leads the charge as the first to introduce
Ultraflux dialysis in Noida and Greater Noida, offering this advanced treatment at ₹5,000–₹5,500
per session. This guide breaks down what Ultraflux dialysis entails, its mechanism, and its
advantages, written for the public with supporting scientific references.
What is Ultraflux Dialysis?
Ultraflux dialysis is an advanced hemodialysis technique utilising a high-flux dialyser, like the
NIPRO HX, to more effectively eliminate a wider array of waste from the blood compared to
traditional dialysers. Hemodialysis serves as an artificial filter for toxins, excess fluids, and
electrolytes when the kidneys fail. The “Ultraflux” label stems from the high-flux membrane in
the NIPRO HX, featuring larger pores that target larger molecules, including
immunoglobulin-free light chains (FLCs), which pose risks in diseases like multiple myeloma.
Unlike conventional low-flux dialysers that focus on small molecules like urea and creatinine,
the NIPRO HX, a high cut-off (HCO) device, can remove substances up to 40,000 Daltons (Da),
such as kappa (κ) FLCs (22,000 Da). This positions Ultraflux dialysis as a vital option for
specific kidney ailments, with Renacare Dialysis spearheading its application in Noida and
Greater Noida.
How Does Ultraflux Dialysis Work?
During Ultraflux dialysis, blood is extracted from the patient and circulated through the NIPRO
HX dialyser, which houses thousands of minuscule hollow fibres. These fibres create a
semipermeable membrane that separates blood from a purifying fluid known as dialysate, crafted
with ultrapure dialysis water to reduce contamination risks. The high-flux membrane facilitates
the transfer of toxins and larger molecules from the blood to the dialysate via diffusion, where
substances shift from higher to lower concentration areas. The waste-laden dialysate is then
discarded, and the cleansed blood is returned to the patient.
Dr.
Anil Bhatt
Unlike some high-flux systems that depend on convection (pressure-driven filtration), Ultraflux
dialysis with the NIPRO HX relies solely on diffusion, enhanced by the ultrapure dialysis water.
This water, devoid of bacteria and endotoxins, ensures a safer dialysis process, lowering
inflammation risks. The NIPRO HX’s diffusion-based approach to targeting larger molecules
makes it especially effective for conditions like myeloma cast nephropathy, where FLCs obstruct
the kidneys and trigger acute kidney injury (AKI).
Benefits of Ultraflux Dialysis
Ultraflux dialysis, provided by Renacare Dialysis using the NIPRO HX dialyser, offers multiple
advantages over traditional hemodialysis, particularly for patients with complex kidney issues.
Here are the key benefits, explained plainly:
1. Improved Toxin Clearance
The NIPRO HX’s high-flux membrane excels at removing larger molecules, such as
κ-FLCs, which are toxic in multiple myeloma. A case study noted an 81% drop in κ-FLC
levels after two weeks of Ultraflux dialysis, highlighting its ability to eliminate these
harmful proteins and support kidney function in cast nephropathy cases.
2. Affordable Treatment
Priced at ₹5,000–₹5,500 per session at Renacare Dialysis centers, Ultraflux dialysis is a
budget-friendly alternative to other HCO dialysis options, improving access and reducing
financial strain on patients and healthcare systems.
3. Better Health Outcomes
By removing a broader spectrum of toxins, Ultraflux dialysis can enhance overall
well-being. For multiple myeloma patients, lowering FLC levels may slow kidney
deterioration and delay long-term dialysis needs, with early data suggesting improved
renal recovery when paired with effective chemotherapy.
4. Specialised for Complex Conditions
Ultraflux dialysis is ideal for patients with diseases like multiple myeloma, where
standard dialysis struggles to address large molecule buildup. The NIPRO HX’s
diffusion-based targeting of κ-FLCs (though not λ-FLCs, at 45,000 Da) offers a tailored
solution for specific kidney injuries.
5. Lower Inflammation with Ultrapure Water
The use of ultrapure dialysis water at Renacare minimises bacteria and endotoxins in the
dialysate, reducing inflammation—a common dialysis complication that can worsen
health. Research indicates that ultrapure water decreases inflammatory markers like
C-reactive protein, boosting patient comfort.
Who Can Benefit from Ultraflux Dialysis?
Ultraflux dialysis, now accessible at Renacare Dialysis centres in Noida and Greater Noida, is
especially advantageous for:
Dr.
Anil Bhatt
● Multiple Myeloma Patients: Those with κ-FLC-related kidney damage (cast
nephropathy) see notable reductions in harmful proteins.
● Acute Kidney Injury (AKI) Patients: Ultraflux helps manage toxin accumulation in
AKI linked to specific conditions.
● High-Flux Dialysis Candidates: Patients needing superior clearance of larger molecules
beyond standard dialysis capabilities.
However, it may not suit everyone. Its limited effectiveness against lambda (λ) FLCs due to their
larger size is a consideration. A Renacare nephrologist will assess suitability based on individual
health needs.
Challenges and Considerations
While Ultraflux dialysis brings notable benefits, it faces some hurdles:
● Limited Research: Evidence largely stems from case studies or small trials (e.g.,
Nephron Clinical Practice), with larger studies needed to confirm long-term benefits for
kidney recovery and survival.
● Ongoing Dialysis Needs: Severe kidney damage may leave some patients
dialysis-dependent, as seen in a case where a patient passed away despite FLC reduction.
● Regional Availability: Though Renacare pioneers Ultraflux dialysis in Noida and
Greater Noida, access elsewhere may be restricted, though the ₹5,000–₹5,500 session
cost locally enhances accessibility.
Renacare Dialysis: Leading Ultraflux Dialysis in Noida and Greater Noida
Renacare Dialysis takes pride in being the first to offer Ultraflux dialysis in Noida and Greater
Noida, utilising the advanced NIPRO HX dialyser at ₹5,000–₹5,500 per session. Committed to
innovative technology and patient-focused care, Renacare is reshaping kidney treatment in the
region. By integrating Ultraflux dialysis with ultrapure dialysis water, Renacare delivers top-tier
care for complex kidney conditions, blending affordability with progress.
The Future of Ultraflux Dialysis
Ultraflux dialysis, driven by the NIPRO HX dialyser and ultrapure dialysis water, signals a major
advancement in personalised kidney care. Ongoing research may expand its applications and
solidify its benefits. Innovations in high-flux membranes and water purification could further
refine Ultraflux dialysis, potentially making it a standard treatment. Renacare Dialysis remains at
the cutting edge, ensuring patients in Noida and Greater Noida reap these benefits.
Dr.
Anil Bhatt
Conclusion
Ultraflux dialysis, available at Renacare Dialysis in Noida and Greater Noida via the NIPRO HX
dialyser and ultrapure dialysis water for ₹5,000–₹5,500 per session, represents a transformative
step in hemodialysis. Its ability to clear a wider range of toxins through diffusion, combined with
affordability and reduced inflammation, makes it a crucial option for patients with complex
kidney issues like multiple myeloma. Though further research is needed to validate long-term
outcomes, early results are encouraging. If you or a loved one requires dialysis, reach out to
Renacare Dialysis to see if Ultraflux dialysis is a fit.
With cutting-edge technology and compassionate support, Renacare Dialysis is empowering
patients to lead healthier, fuller lives—one session at a time.
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Myeloma, Kidney Failure, High-Flux Dialyzer, Ultrapure Water, Acute Kidney Injury, Cast
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References
1. Effective Removal of κ-Free Light Chains with Hemodialysis Using High-Flux Dialyser
in a Patient with Myeloma Cast Nephropathy. Nephron Clinical Practice. Available at:
www.karger.com.
2. Ultrapure Dialysis Fluid: A New Standard for Contemporary Hemodialysis. PMC.
Available at: www.ncbi.nlm.nih.gov.
3. Sakhuja V, Jha V, Varma S, et al. Renal involvement in multiple myeloma: a 10-year
study. Ren Fail. 2000;22:465-477.
4. Zannetti BA, Zamagni E, Santostefano M, et al. Bortezomib-based therapy combined
with high cut-off hemodialysis is highly effective in newly diagnosed multiple myeloma
patients with severe renal impairment. Am J Hematol. 2015;90:647-652.
5. Web search results on high-flux dialysis and ultrapure water, confirming the role of
diffusion and water quality in reducing inflammation.